Though not filmed here, there are several reference to Scranton in the 1996 Farley Brothers comedy Kingpin.
The film tells the hilarious story of Roy Munson (Woody Harrelson), a champion bowler in 1979 who loses his bowling hand after a misunderstanding with a gang (and some underhandedness from his rival Ernie McCracken, played by Bill Murray).
"Scranton, Pennsylvania, 17 years later" then appears on the screen.
Now with a prosthetic hand and all of his bowling career hopes smashed, he meets Ishmael (Randy Quaid) , a talented bowler (and Amish man) whom Roy takes under his wing. (in the film, Scranton and Amish Country are just a drive away from each other).
Listed in the credits of Kingpin as Scranton Wino is actor Herbie Flynn (b. September 18, 1917; d. February 11, 2003), who played similar roles in three other Farley Brothers films---There's Something About Mary; Shallow Hal; and Me, Myself & Irene.
Kingpin is available on DVD and VHS from the Lackawanna County Library System. Click here to place a hold on the DVD; if you'd rather borrow VHS, click here.